Vero – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants
[DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article

UV 222 disinfection of SARS-CoV-2 in solution

용액 내 SARS-CoV-2의 UV 222 소독

Article

Published on 2022-08-252022-09-11
Journal: Scientific Reports
[Category] SARS, 치료법,

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease

SARS-CoV-2 주요 프로테아제의 신규 억제제로서의 2-(푸란-2-일메틸렌)히드라진-1-카르보티오아미드 유도체의 발견

Article

Published on 2022-08-052022-09-11
Journal: European journal of medicinal chemistry
[Category] COVID19(2023년), SARS, 치료제,

Proper Selection of In Vitro Cell Model Affects the Characterization of the Neutralizing Antibody Response against SARS-CoV-2

체외 세포 모델의 적절한 선택은 SARS-CoV-2에 대한 중화 항체 반응의 특성화에 영향을 미칩니다

Article

Published on 2022-06-072022-09-11
Journal: Viruses
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] antibody Antibody Response BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine Calu Calu-3 cell line cell lines cellular characterization characterized choice collected correlation COVID-19 COVID-19 vaccine Cytopathic effect cytopathic effects demonstrated Entry mechanism entry mechanisms evaluated in vitro increasingly inhibitory activity lack mechanisms Model mRNA mRNA vaccine natural infection Neutralizing Neutralizing activity neutralizing activity. occur of BNT162b2 PCR pseudovirus pseudoviruses response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 viral Selection sera Single Cell subject Surrogates TMPRSS2 vaccine-induced antibodies vaccine-induced antibody variants Vero Vero E6 Viral viral entry viral entry pathway virus particles VOCs
[DOI] 10.3390/v14061232 PMC 바로가기 [Article Type] Article

High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients

HERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다

Article

Published on 2022-05-072022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

[Increased LAMP1 Expression Enhances SARS-CoV-1 and SARS-CoV-2 Production in Vero-Derived Transgenic Cell Lines]

Article

Published on 2022-05-012023-07-09
Journal: Molekuliarnaia biologiia
[Category] COVID19(2023년),

[키워드] COVID-19 LAMP1 SARS-CoV-1 SARS-CoV-2 transgenic cells. Vero
[DOI] 10.31857/S0026898422030053 PMC 바로가기

Replication kinetics and infectivity of SARS-CoV-2 variants of concern in common cell culture models

일반적인 세포 배양 모델에서 우려되는 SARS-CoV-2 변이체의 복제 동역학 및 감염성

Article

Published on 2022-04-262022-09-11
Journal: Virology Journal
[Category] COVID19(2023년), SARS, 변종,

[키워드] African airway Alpha antibody B.1.617.2 Beta Caco-2 Calu Calu-3 caused Cell culture cell culture supernatant cell culture supernatants cell line cell lines Colon concern conducted coronavirus different time point different time points Drug screening epidemiological epithelial experimental design FIVE Genome green growth human cell line human cell lines immunological in viral Infection information investigated kidney Kinetics mutations omicron pandemic pathogenic Post-infection Propagation provide replication kinetics Research researcher SARS-CoV-2 SARS-CoV-2 variant several variants Support the SARS-CoV-2 Vero Vero E6 viral particle Viral particles viral replication kinetics Viral RNA virus virus isolation viruses VoC VOC. VOCs
[DOI] 10.1186/s12985-022-01802-5 PMC 바로가기 [Article Type] Article

Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

재조합 인간 인터페론-α1b는 시험관 내에서 인터페론-α2b보다 SARS-CoV-2를 더 잘 억제합니다

Article

Published on 2022-04-012022-09-11
Journal: Virologica Sinica
[Category] COVID19(2023년), SARS, 치료제,

[키워드] anti-SARS-CoV-2 Antiviral effect Calu-3 comprehensive evaluation drug immunofluorescence in vitro inhibit qPCR recombinant SARS-CoV-2 shown TCID therapy Vero
[DOI] 10.1016/j.virs.2022.01.031 PMC 바로가기 [Article Type] Article

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응

Article

Published on 2022-03-092022-09-11
Journal: Journal of Virology
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type
[DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

감염성 SARS-CoV-2 B.1.1.529 Omicron 바이러스는 치료용 단일 클론 항체에 의한 중화를 피합니다

Article

Published on 2022-03-012022-09-11
Journal: Nature Medicine
[Category] Fulltext, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-receptor-binding domain antibody AstraZeneca B.1.1.529 Biotechnology Celltrion Clinical use Combination concerning coronavirus decrease Efficacy Lilly LY-CoV555 mAb mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron parent reduced Regeneron REGN10933 REGN10987 respiratory S309 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sotrovimab Spike protein tested the antibody the spike protein therapeutic TMPRSS2 TMPRSS2 cells variant Vero Vero-hACE2-TMPRSS2 cells Vir virus
[DOI] 10.1038/s41591-021-01678-y PMC 바로가기 [Article Type] Article